Stack Lab Research Overview
Understanding the molecular mechanisms by which tumor cells orchestrate multiple microenvironmental cues to regulate metastasis is the major focus of the Stack Lab.
Current research in the Stack Lab centers on the regulation of adhesion and extracellular proteolysis in two model systems: epithelial ovarian carcinoma and squamous cell carcinoma of the oral cavity. Ongoing research utilizes an integrative approach involving the examination of 2D and 3D tissue culture systems and organotypic cultures complemented by murine tumor models and analyses of human tumors.
Sharon Stack
Kleiderer-Pezold Professor of Chemistry & Biochemistry
Ann F. Dunne & Elizabeth Riley Director of the Harper Cancer Research Institute
Investigators in the Harper Cancer Research Institute are dedicated to conducting innovative and integrative research that confronts the complex challenges of cancer.