Stack Lab Research Overview

Understanding the molecular mechanisms by which tumor cells orchestrate multiple microenvironmental cues to regulate metastasis is the major focus of the Stack Lab. 

Current research in the Stack Lab centers on the regulation of adhesion and extracellular proteolysis in two model systems: epithelial ovarian carcinoma and squamous cell carcinoma of the oral cavity. Ongoing research utilizes an integrative approach involving the examination of 2D and 3D tissue culture systems and organotypic cultures complemented by murine tumor models and analyses of human tumors. 

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Sharon Stack

Kleiderer-Pezold Professor of Chemistry & Biochemistry

Ann F. Dunne & Elizabeth Riley Director of the Harper Cancer Research Institute